Webb18 juni 2024 · The thymus has developed several control mechanisms to simultaneously establish T cell immunity against non-self elements and impose self-tolerance. Particularly important in the choreography of T cell selection are thymic epithelial cells (TECs), which represent a key component of the thymic stromal microenvironment. Webb20 jan. 2004 · Medullary thymic epithelial cells overexpress a highly diverse set of genes (>400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes.
Thymic epithelial cell heterogeneity: TEC by TEC - Nature
Webb5 dec. 2024 · Historically (left panel), medullary thymic epithelial cells (mTECs) and cortical thymic epithelial cells (cTECs) were differentiated using only a small number of … Webb5 apr. 2024 · It is proposed that acute irradiation persistently disturbs the heterogeneity and properties of mTECs, and may thereby impair TSA expression for thymic T cell selection. The thymus has the ability to regenerate from acute injury caused by radiation, infection, and stressors. In addition to thymocytes, thymic epithelial cells in the medulla … buddys market market contact number
Differentiation of induced pluripotent stem cells to thymic …
Webb31 jan. 2024 · Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development. The thymus is the primary lymphoid organ responsible for the generation and maturation … Webb23 juli 2024 · Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality Front Immunol. 2024 Jul 23;9:1663. doi: … WebbFör 1 dag sedan · Thymic medullary epithelial cells with high AIRE expression are prone to apoptosis and release TSAs that will be captured by dendritic cells and presented to CD4 + CD8 + T cells through MHC. T cells that overreact undergo apoptosis, while surviving T cells recognize TSAs presented by MHC class I/II and develop into CD4 + CD8 − or CD4 − … buddy smart reel