Phosphopantetheine attachment site

Author: bjzz

August undefined, 2024

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier … Hei Sook Sul, ... Li Chen, in Progress in Nucleic Acid Research and Molecular …

US20050107308A1 Dipeptidyl peptidase IV inhibitors and their …

WebThe human NDUFAB1 protein contains a phosphopantetheine attachment site (DLGLDSLDQVEIIMAM), unique for acyl carrier proteins, and an EF-hand calcium binding … WebSep 1, 2000 · Motifs I and III have been associated with ATP-binding and hydrolysis activities, respectively, since motif X contains a conserved serine to which a 4′-phosphopantetheine cofactor is very probably attached [ 3 ]. eagle bar nyc

SMART: PKS_PP domain annotation

Web4'-Phosphopantetheine C11H23N2O7PS CID 115254 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebDownload scientific diagram Phylogenetic analysis of CARs. A) Domain organization of CAR sequences: adenylation domain (PFam PF00501), phosphopantetheine (PP) … WebPromotional Article Monitoring. Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. eagle bar new orleans

ACP phosphopantetheine attachment site binding …

Identification of sites subjected to serine/threonine …

WebOct 1, 2024 · Genome sequencing, comparative genomic analysis, and gene disruption of Streptomycessp. SYP-A7193 showed that the inthomycin biosynthetic gene cluster (itm) belonged to the hybrid polyketide synthase (PKS)/nonribosomal peptide … WebPhosphopantetheine attachment site Provide feedback. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. cshp radiology medical center pointWeb[0005] This invention relates to a method of treatment, in particular to a method for lowering blood pressue levels in mammals and to compounds and compositions for use in such me cshp residency programs

"WebApr 26, 2024 · In addition, it showed a close relationship with the phosphopantetheine attachment site protein (IPR006162) and acyl carrier protein of super family SSF47336 (IPR009081). It also shares similarities with the peptide chains of IPR020806 polyketide synthase, phosphopantetheine-binding domain, and others including IPR020845, … " - Phosphopantetheine attachment site

Phosphopantetheine attachment site

AmiGO 2: Term Details for "acyl carrier activity" (GO:0000036)

WebJan 10, 2024 · To obtain active CAR enzyme, a phosphopantetheine group must be attached covalently to a conserved serine in the PCP domain mediated by a suitable … Webphosphopantetheine (or pantetheine 4' phosphate) (Ppant) prosthetic group that is covalently attached to an invariant serine residue of the CP domain. CP domains, typically …

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WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. WebDec 6, 2013 · For NRPS, the domains are: adenylation (A), condensation (C), oxidation (Ox), thioesterase (Te) and 4-phosphopantetheine attachment site (PP). Figure 3. Alignment of the PKS/NRPS cluster at genomic coordinates of 3092397–3133943 in D. solani D s0432-1 with the two closest homologs in D. zeae Ech586 and T. turnerae T7901. The improved ...

WebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Definition: Interacting selectively and non-covalently with the attachment site of the … WebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Alternate IDs None Definition Binding an acyl group and presenting it for processing or …

WebSep 2, 2014 · There is a phosphopantetheine attachment site spanning residues G 143 to M 164 in AhDGAT1-1 (G 157 to M 178 in AhDGAT1-2). A putative thiolase acyl-enzyme intermediate binding motif, previously cited in the Arabidopsis sequence by Zou et al. (1999) , is also found in AhDGAT1. It contains an invariant Pro208 at the N-terminus of this motif … WebAug 16, 2024 · Most chemical modifications made to proteins within cells occur after the protein is synthesized in a process called translation. The resulting chemical changes are …

WebAug 23, 2024 · PDOC00012 1 Phosphopantetheine attachment site PDOC00013 1 Prokaryotic membrane lipoprotein lipid attachment site PDOC00342 1 Prokaryotic N …

Webreductase; KR, ketoreductase; PP, phosphopantetheine attachment site (acyl carrier pro-tein of PKSs and thiolation of NPSs); AMP, adenylation; CON, condensation; HGT, horizon-tal … eagle bar nyc eventshttp://amigo.geneontology.org/amigo/term/GO:0000036 eagle barrow clitheroeWebDefinition: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. ID: GO:0000036 Synonyms: Articles referencing this term. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork ... cshp region 2WebMay 28, 2010 · The amino acid sequence of NDRG1/Cap43 has been reported to bear a phosphopantetheine attachment site, an α/β hydrolase fold and three tandem repeats [15], [19], as well as a few sites that are phosphorylated by SGK [20] (Fig. 1 A). Western blotting revealed that NDRG1/Cap43 protein had several bands with different mobilities, including … cshp registration seminarWebMar 23, 2024 · It has 12 putative transmembrane domains and intracellular N and C termini. SLC26A1 contains a sulfate transporter signature, a phosphopantetheine attachment site, … eagle barnsWebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Alternate IDs None Definition Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme ... eagle-barrett syndrome fact sheethttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 eagle barrow