http://dulab-tsinghua.net/index.php?id=362 WebLysyl oxidase (LOX) is a copper-dependent monoamine oxidase whose primary function is the covalent cross-linking of collagen in the extracellular matrix (ECM). …

An in situ activity assay for lysyl oxidases Communications Biology

WebIntroduction: Enzymatic cross-linking of the collagens within the extracellular matrix (ECM) catalyzed by enzymes such as lysyl oxidase (LOX) and lysyl oxidase like-enzymes 1–4 (LOXL), transglutaminase 2 (TG2), and peroxidasin (PXDN) contribute to fibrosis progression through extensive collagen cross-linking. WebLysyl oxidase (LOX) is another example of a copper-dependent AO; it functions to crosslink and stabilize collagen and elastin fibers, thus being involved in connective tissue formation. LOX uses lysyl tyrosyl quinone as a cofactor, which is required for its catalytic activity in the extracellular matrix (Kagan and Li, 2003 ). byrut god of war

Visualizing cross-linking in collagen - Chemical & Engineering News

WebThe amount of LOX-mediated collagen cross-links in plaques correlated positively also with serum levels of OPG. Conclusions: Lysyl oxidase may contribute to the … Web26 oct. 2014 · Enzymes involved in collagen biosynthesis, including lysyl oxidase (LOX), have been proposed as potential therapeutic targets for idiopathic pulmonary fibrosis. LOX expression is significantly upregulated in bleomycin (BLM)-induced lung fibrosis, and knockdown of LOX expression or inhibition of LOX activity alleviates the lung fibrosis. Web25 sept. 1976 · In this paper, the synthesis of collagen cross-links in vitro was investigated in a defined system consisting of highly purified chick cartilage lysyl oxidase and … byrut hogwarts