Web1 day ago · The need for immunosuppressive drugs is one major roadblock to using pancreatic islet transplantation to treat diabetes. Hu et al. used CRISPR to knock out the genes encoding class I and II MHC and overexpress CD47 in primary human pancreatic islet cells, making them immune-evasive.The hypoimmune cells were reaggregated into … WebJul 1, 2024 · High-fat diet-induced body weight gain, and body composition was similar in WT, GLP1R-KO, Y2R-KO, and GLP1RKO/Y2RKO mice over the 15 weeks of exposure (Figure 1 A–C).Both fasting glucose and insulin increased with time of exposure to high-fat diet in all groups, with only minor differences, most notably lower fasting insulin levels at …
Combined loss of GLP-1R and Y2R does not alter ... - ScienceDirect
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Small molecule inhibitors and a kinase-dead expressing mouse …
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