Cisplatin pulmonary toxicity

Author: ecoy

August undefined, 2024

WebTUBULAR TOXICITY Platinum compounds Cisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, ovarian, lung, cervical, and bladder cancers. Nephrotoxicity is the dose-limiting toxicity of cisplatin. … WebPubMed Central (PMC)

Cisplatin: a review of toxicities and therapeutic applications

WebApr 8, 2013 · Cisplatin reduces the renal clearance of bleomycin and in doing so may enhance toxicity [ 5 ]. 3. Common Side Effects Skin reactions are the most common side effects and include erythema, … curled cat tail

Cisplatin - an overview ScienceDirect Topics

WebOct 7, 2024 · Depending on a dose (single or cumulative) cisplatin can cause leucocytopenia, thrombocytopenia, and anemia also in mice (toxicity on hemopoietic cells, Figure 1 ). Myelotoxicity can be observed already a day after cisplatin administration and is more toxic for earlier hemopoietic progenitor cells than for the mature cells [ 74 ]. WebMyelosuppression is the most common toxicity of gemcitabine therapy. Pulmonary toxicities due to gemcitabine have, however, been reported. Dyspnea occurs in approximately 25% of patients treated with gemcitabine, whereas serious pulmonary toxicities are much less common, approximately 0.3%. WebIn group 1, cisplatin was administered at a dose of 60 mg/m2 to four cats. In an attempt to avoid renal toxicity, saline diuresis was induced by administering 0.9% saline solution … curled chervil

Oral vinorelbine and cisplatin with concurrent radiotherapy after ...

Adverse Cardiac Manifestations of Cisplatin - A Review

WebSep 6, 2024 · Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of patients and limits the maximum dose that can be delivered, reducing tumor control probability (TCP) and may lead to dyspnea, lung fibrosis, and impaired quality of … WebFeb 2, 2024 · Cisplatin can cause not only nephrotoxicity but also cause severe neurotoxicity, which significantly limits its clinical use. A study showed that a continuous high dose of cisplatin stimulation disrupted the blood-brain barrier, leading to brain cell edema and neuronal necrosis (Namikawa et al., 2000). Regarding the study of prevention and ... curled cat sleepingWebCisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the … curled coir

"WebJan 12, 2024 · Cisplatin has severe nonhematological toxicities, particularly nephrotoxicity and gastrointestinal toxicity. The recent development of new antiemetic therapies has greatly reduced... " - Cisplatin pulmonary toxicity

Cisplatin pulmonary toxicity

Cisplatin Mouse Models: Treatment, Toxicity and Translatability …

WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ... WebAug 1, 1998 · Cisplatin doses were fixed and were not reduced for any toxicity. The most common reasons for irinotecan dose reduction were nausea and vomiting (27% of patients), followed by diarrhea (21%), and neutropenia (12%). Response and Survival All patients were evaluated for response and survival.

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WebDec 1, 2024 · Dose adjustments for both docetaxel and cisplatin were performed according to pre-defined criteria for each type of toxicity (mainly grade 4 neutropenia and grade 3–4 neuropathy). Two dose reductions were allowed for DC75 (first to 60 mg/m 2, second to 50 mg/m 2), but only 1 reduction was allowed for DC60 and DCM therapy (to 50 mg/m 2). … WebToxicity is progressive, occurring over the course of weeks to months. The most strongly associated predictor of neurotoxicity is dose and cases occur with doses approaching 40 mg/m2. Diagnosis...

WebMar 29, 2015 · Cisplatin-based regimens are associated with enhanced efficacy and toxicity as compared with carboplatin-based therapy 32,33; yet in CALGB protocol 9633, 27 33 percent of patients required dose... WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation.

WebSep 15, 2024 · Common side effects include nausea, vomiting, bone marrow suppression, electrolyte imbalance, neuropathy, ototoxicity and nephrotoxicity. Cisplatin is mutagenic, … WebAlthough pulmonary toxicity is seen when cisplatin is used in combination with other chemotherapeutic agents, cisplatin is generally not considered to be the causative …

WebPulmonary toxicity of cytotoxic agents Platinum compounds The administration of cisplatin and carboplatin, the 2 most commonly used platinum derivative agents, can …

WebSep 1, 2024 · Cisplatin for injectioncan cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses of the drug. … curled colony morphologyWebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was … curled chipsWebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary toxicity is covered elsewhere, as is lung toxicity associated with molecularly targeted … curled chicken feetWebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, tachycardia, and hypotension. Hypersensitivity reactions have occurred within minutes of administration to patients with prior exposure toCisplatin for injection. curled corners bookWebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or … curled cordWebDec 7, 2024 · Extensive-stage small cell lung cancer (ES-SCLC) is an aggressive disease with poor survival, and platinum-etoposide chemotherapy is indicated as the mainstay of … curled cornerWebcancer with Cisplatin is 95% with a 25 year risk of cardiovascular toxicity in 16% patients due to direct endothelial damage of Cisplatin or indirectly induced hormonal and … curled cowboy boots