WebJul 12, 2024 · The BUB1B gene is located at chromosome 15q15 and plays a vital role in chromosome segregation . ... Oh S. Pharmacogenomic analysis reveals CCNA2 as a predictive biomarker of sensitivity to Polo-Like Kinase I inhibitor in gastric cancer. Cancers (Basel). 2024;12:E1418. WebFeb 10, 2013 · Although BUB1B is necessary for mammalian development , its essential function is contained solely within the N-terminal KEN box , which enables BUB1B/BubR1 to act as a pseudo-substrate inhibitor of APC/C Cdc20 during G 2 and preanaphase mitosis, preventing a precocious anaphase .
BUB1B gene: MedlinePlus Genetics
WebJun 30, 2024 · In addition, because the inhibitor library that we used did not contain a BUB1B inhibitor, we also performed additional experiments on BUB1B, another top hit identified in the siRNA screen. In the Qiagen siRNA library used for the primary RNAi screening, four pairs of siRNAs were pooled for each target kinase. To eliminate … WebSep 20, 2024 · BUB1B/BUBR1 has been reported as a component of mitotic-checkpoint complex (MCC) and an inhibitor of anaphase-promoting complex/cyclosome (APC/C) [ … small boat called
BUB1 MITOTIC CHECKPOINT SERINE/THREONINE KINASE B; BUB1B
WebApr 4, 2024 · Abstract 2477: Evaluating the effects of Bcl2 inhibitor, venetoclax, on cellular growth and clustering in triple-negative breast cancer cells April 2024 Cancer Research 83(7_Supplement):2477-2477 WebOct 10, 2004 · It is a potent inhibitor of APC/C, ... Bub1b H/H mice also show features of premature aging. But individuals with MVA do not have typical features of human premature aging syndromes. WebBackground. The Mitotic Checkpoint Complex (MCC), which contains Bub1, Bub1b, Bub3, Mad2, and Cdc20, controls chromosome segregation and monitors kinetochore-microtubule interactions (1). During mitosis, the MCC complex inhibits the ubiquitin ligase activity of the Anaphase Promoting Complex/Cyclosome (APC/C), thereby preventing cells with ... solution focused approach social work uk